I install DMZhaloR on every Linux system I use, then set the size to 40 or higher depending on my computer's resolution (the cursor sizes range from 24px to 64px.) It's the standard DMZ white cursor theme with black outlines but with an added red halo effect. I have vision issues (glaucoma, nearsightedness, increasing farsightedness as I grow older, astigmatism, detached retinas in the past, past cataracts) and used to have problems finding my mouse cursor, but not any more. This puppy is visible against any background color except maybe a mixture or red, black and white (ouch!) The white stands out against dark backgrounds, the black outline is easily seen against light backgrounds, and the red halo stands out against practically everything else. You can't lose that!
BTW, I highly recommend adding this cursor theme as one of the available ones in MX Linux for accessibility reasons.